The Endocannabinoid System : The Science Behind CBD

"The discovery of the endocannabinoid system is the single most important medical scientific discovery ever and will save more lives than the discovery and application of sterile surgical technique." Dr. David Allen, distinguished heart surgeon and ECS researcher

Why Does CBD Work So Well For Such a Broad Range of Ailments?

The question above is one of the most common FAQ's for health and fitness consumers new to the world of CBD, the popular abbreviation for "cannabidiol". As scientific research accumulates, CBD has emerged as the most beneficial cannabinoid found in the Sativa L plant family, the species which includes both hemp and marijuana. The key to answering this most common FAQ is to understand how CBD works in natural harmony as a vital supplement to the incredible endocannabinoid system (ECS) found in humans and in fact, all mammals.

CBD is a Natural Supplement

CBD from hemp can get you better without giving you an undesired high, making it one of the safest health supplements in the household, suitable for busy active adults, children, and even pets, (as long as they are mammals!). Why is CBD classified as a supplement rather than a synthetic medication? As we'll see shortly our bodies are already producing a natural supply of cannabinoids, and our human physiology is already "pre-wired" to make the best use of CBD. "Endo" is the Greek term for "internal" or "within", so naturally produced cannabinoids are known as "endocannabinoids".

Discovery of the Endocannabinoid System

Raphael Mechoulam, widely known today as the grandfather of cannabis therapy, was the first researcher to delve into the exact causes of the powerful effects of cannabis on the human mind and body. He was the first to isolate the cannabinoids CBD and THC as the most active compounds of the cannabis species. Mechoulam discovered that important regions of the brain had specific receptors for these two cannabinoid compounds, specialized neurotransmitters in such high quantity that the Israeli chemist knew they must have important roles to play in human physiology. He defined these receptors as "CB1" and "CB2", and soon after discovered that humans, and in fact all mammals, produce the compounds which activate these receptors naturally.

The CB1 and CB2 receptors are located in the vitally important limbic and paralimbic regions of the brain as well as in organs and tissue throughout the body. These brain regions just happen to regulate critical biological and mental processes including:

  • Sleep
  • Mood
  • Inflammation response and injury recovery
  • Immune response to infection or disease
  • Anxiety response
  • Stress response
  • Appetite
  • Memory and cognitive thought processes
  • Pain tolerance and control
  • Physical Coordination
  • Hormonal balance
  • Blood sugar regulation

Homeostasis and the ECS

The overall mission of the ECS is to maintain the mind and body in a balanced state of overall well being which scientists refer to as the process of "homeostasis". CB1 receptors are intensely located in the brain with some dispersal throughout the body. CB2 receptors are also found in the ECS center of the brain but they are even more widely distributed throughout important systems of the body including the digestive system, kidneys, and liver. Together the receptors provide an intricate biofeedback network of neurotransmitters to regulate all of the important functions listed above.

The biofeedback network allows the ECS to adapt to environmental conditions to moderate pain, fight off disease, and even to handle the daily stresses we all encounter in life on planet earth. When "all systems are go" our bodies have an adequate supply of endocannabinoids, homeostasis is maintained, and we find ourselves living happily in what some scientists call "the Goldilocks Zone", where everything is just right.

Clinical Endocannabinoid Deficiency (CECD)

There are times though when the ECS can be overwhelmed when we find ourselves under extreme stress, fighting off infection or disease, recovering from surgery or injuries, experiencing acute anxiety and insomnia, or dealing with chronic pain and inflammation. Some scientists believe that extreme conditions such as these can leave the ECS in a state of "clinical endocannabinoid deficiency". This condition occurs when the natural supply of endocannabinoids can use a boost to provide the ECS with the fuel it needs to maintain homeostasis and get the mind and body back on track to the Goldilocks Zone. Scientists today are still researching the concept of endocannabinoid deficiency to explain the powerful known therapeutic action of supplemental CBD for alleviating the disruptive symptoms of treatment-resistant conditions such as:

  • migraine headaches
  • fibromyalgia
  • irritable bowel syndrome
  • depression
  • PTSD (post-traumatic stress disorder)

Science is still catching up on just how supplemental cannabinoids such as CBD can enhance ECS function, but according to a Cannabis and Cannabinoid Research Report at the National Institute of Health:

" Clinical data have produced evidence for decreased pain, improved sleep, and other benefits to cannabinoid treatment and adjunctive lifestyle approaches affecting the ECS."

That's certainly no surprise for the multitude of satisfied CBD consumers around the world, all enjoying the many benefits which come with a well-maintained endocannabinoid system.

About Radius CBD

The founders of Radius CBD are caregivers, cultivators, and innovators, all dedicated to providing 100% natural US-sourced CBD products that can keep your mind and body in the Goldilocks Zone. All of our CBD products contain less than .03% THC which makes them completely legal in all 50 states. We offer CBD in tinctures and capsule form, in a variety of dosages, all lab tested and competitively priced to suit your personal CBD fitness regimen.